HIV/AIDS News Alert

Updated Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents

U.S. Department of Health and Human Services (HHS), January 28, 2016
The HHS Panel on Antiretroviral Guidelines for Adults and Adolescents announces the release of the updated Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Key updates to the guidelines are largely based on findings from the START and TEMPRANO trials demonstrating the clinical benefits of early initiation of antiretroviral therapy (ART) (i.e., pre-treatment CD4 count threshold >500 cells/mm3).
Key guideline updates include the following:

  • Based on the START and TEMPRANO findings, the Panel has increased the strength and evidence rating for the recommendation on initiating ART to AI for all HIV-infected patients, regardless of CD4 count.
  • Although adolescents were not included in the START or TEMPRANO studies, based on the expectation that adolescents will derive benefits from ART similar to those observed in adult trial participants, the Panel's recommendation to treat all HIV patients includes adolescents.
  • Given the recommendation to treat all patients, the Panel has increased emphasis on treating older adults and those diagnosed with acute and recent infection.
  • In November 2015, the Panel added elvitegravir/cobicistat/tenofovir. alafenamide/emtricitabine for patients with estimated creatinine clearance ≥30 mL/min (AI) as a recommended regimen for initial therapy. Detailed discussion regarding this regimen will appear in the next revision of the guidelines.

For a complete preview of key updates to the guidelines, please see What's New in the Guidelines. Additions and revisions are also highlighted in yellow throughout the text and tables of the PDF version of the guidelines.
To view or download the guidelines, go to the Adult and Adolescent ARV Guidelines section of AIDSinfo. Separate PDF files of only the guideline tables or the boxed recommendations can also be downloaded from the page.
Forward Comments on the Revised Guidelines to AIDSinfo.
Feedback on the revised Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents is welcome. Please email your comments with the subject line "Comments on the Adult and Adolescent ARV Guidelines" to [email protected] by February 12, 2016.

February 7th is National Black HIV/AIDS Awareness Day

February 7th marks the 15th annual observance of National Black HIV/AIDS Awareness Day (NBHAAD). Led by the Strategic Leadership Council, this initiative is designed to increase HIV education, testing, community involvement, and treatment among black communities across the nation.
Connect with African American clients and patients and share these federal resources with your colleagues
Visit these Federal websites:

Go to AIDSinfo for more info and resources. or


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